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In the landmark STEP 1 trial (Once-Weekly Semaglutide in Adults with Overweight or Obesity, Wilding and colleagues, New England Journal of Medicine , 2021), 1,961 adults who took weekly semaglutide (2.4 mg) plus lifestyle support lost a mean of 14.9% of their body weight over 68 weeks, compared with 2.4% on placebo, and 86% achieved at least 5% weight loss
It works in the same way as semaglutide to reduce appetite and keep you feeling full between meals
CMS is calling this a "bridge" because it is an 18-month demonstration intended to gather data on cost, utilization, and clinical outcomes
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