All five long-acting GLP-1RAs can reduce glucose levels and BW [4, 22, 23, 26, 27]
Elahi et al.Obesity (Silver Spring)
FDA-approved under brand names such as Zepbound and Mounjaro, tirzepatide has demonstrated weight loss exceeding 20% in some clinical studies
Medical check-ins monitor progress, control side effects such as nausea or digestive issues, and fine-tune treatment when necessary
Novo Nordisks own indirect treatment comparison (the ORION study, presented at Obesity Medicine Association 2026) suggested greater weight loss with oral semaglutide than with orforglipron, though that analysis was industry-funded and drew skepticism from independent researchers
Use mixed greens, cherry tomatoes, cucumbers, and grilled chicken or tofu