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This strategy also coordinates downstream cyclic nucleotide-dependent cascades, including PKA-mediated phosphorylation of ERK, CREB, and DARPP-32, optimizing synaptic plasticity, neuronal excitability, and behavioral outcomes, and providing a rationale for comprehensive symptom management with reduced off-target effects

All VYVANSE dose groups were superior to placebo in the primary efficacy outcome

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No medication replaces the need for balanced nutrition and regular physical activity

have existing health conditions

Taken together, the flux-constraint perspective reframes GLP-1RA therapy as a systemic metabolic state in which therapeutic durability depends on maintaining proportionality between oxidative throughput and substrate-supported regenerative capacity