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High concentrations administered intravenously can be diluted using parenteral infusion solutions

It is a known side effect, and it is manageable

Menon AV, Liu J, Tsai HP, Zeng L, Yang S, Asnani A, et al

For the 579 patients who were randomized, mean body weight at enrollment prior to entering the 12-week lifestyle lead-in period (Week -12) was 109.5 kg and mean BMI was 38.6 kg/m2

While the clinical significance of this interaction remains uncertain, women relying on oral contraceptives for pregnancy prevention should be counseled about the potential for reduced efficacy and may need to consider additional contraceptive methods, particularly during the initial weeks of therapy when gastric emptying delay is most pronounced

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