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Gastrointestinal side effects appear to be more pronounced in oral formulations, while injectable administration can cause injection site irritation [14]

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Active-comparator new-user cohort studies with an appropriate design have consistently demonstrated dementia risk reduction with SGLT2 inhibitor users with diabetes across different regions [12,13,14,15,16,17,18,19,20]

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Limitations 1 : 1 : Results should be interpreted with caution because of the retrospective pre-post design without a control or comparator arm and the relatively short follow-up (6 months) Hypoglycemia may have been underreported, as only the clinically significant events were likely to have been captured (eg, no SMBG or CGM data) EMR database analysis as a potential for selection bias that cannot be controlled, as well as EMR data-capture challenges (eg, coding errors, no dosing data) Patients were mainly from the Northwest and Southern US states and therefore may not be representative of the US national landscape Sanofi-sponsored study *Follow-up period 6 months included GLP-1 RA + Toujeo (N=271)

But, they be very unlikely to even touch on the issues of building the evidence around them, just as they haven't for dietary supplements in disease states