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If it is diet, medication or vitamin related, then it should go away when you stop taking that diet or medicine

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Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose

Additionally, the absorption process itself is competitive, with amino acids and other nutrients vying for uptake in the small intestine

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Rotate the specific site around the knee: medial joint line one day, superomedial the next, inferomedial after that