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COX-2 is an N-glycoprotein with 4 glycosylation sites 33 , and it has been shown that inhibition of COX-2 N-glycosylation by site-directed mutagenesis or pharmacologically using an N-glycosylation inhibitor leads to the production of a COX-2 protein with reduced molecular mass and activity 34

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Patel M, Loree JM, Taggart MW, Malpica A, Matamoros A, Kopetz S , Varadhachary GR, Fournier KF, Royal RE, Raghav KPS

Shroyer NF, Wallis D, Venken KJT, Bellen HJ, Zoghbi HY

Director del Centro de Salud Universitario Pinto