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This is because tissues like the Achilles tendon or rotator cuff are highly avascularthey get very little blood flow
doi: 10.1016/j.cmet.2022.07.013
GPR40, G protein-coupled receptor 40
Sriharsha M, Reddy KN, Darsini TP, Reddy KS
It has also been demonstrated that mitophagy is capable of interfering with cardiomyocyte survival by affecting DRP1 [64]
The mechanisms behind this upregulation appear to involve: Activation of the Nrf2 pathway, which controls the expression of various antioxidant enzymes including GR Modulation of cellular signaling cascades that respond to redox status Alteration of mitochondrial metabolism, influencing NADPH availability for GR activity Reduction of inflammatory signaling that can suppress antioxidant enzyme expression These effects suggest that hydrogen water may provide a "hormetic" stimulusa mild oxidative challenge that triggers beneficial adaptive responses in cellular antioxidant systems
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