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Excess food intake or rapid gastric emptying that exceeds the absorptive capacity of the upper small intestine increases the amount of unabsorbed nutrients in the lumen of the more distally located small intestine, thereby increasing the amount of GLP-1 secretion

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239 Furthermore, autophagy impairmentconsidered a downstream event of mitochondrial dysfunctionhas been associated with ER stress and disordered lipid metabolism, eventually contributing to the development of AP