GLP-1 agonists exert anti-hypertensive effects compared to placebo [69], reducing systolic blood pressure by 23 mmHg
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In addition, they are being explored for their implications in reducing the risk of cardiovascular disease and cancer, and treating high blood pressure, kidney disease, autoimmune diseases and other conditions such as sleep apnea, fatty liver disease, Alzheimers disease, smoking cessation and substance use disorder
Clinical trials have generally started participants on a 2 mg once-weekly retatrutide dosage, with doses increasing at approximately four-week intervals until the planned maintenance dose is reached
Canadian Medical Association Journal, 196 (43), E1413
