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I argued last year that the GLP1a drug semaglutide was disease-modifying in patients with established heart disease and obesity because the SELECT trial showed reductions in hard clinical endpoints

If side effects are intolerable on one, switching to the other is a reasonable option

they represent different regulatory pathways serving different patient populations and cost structures

doi:10.1186/s12958-018-0323-4

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A Note on Eating Disorders & Mental Health It is important to acknowledge that for people with a history of disordered eating, GLP-1 medications may trigger or worsen their illness - primarily due to the psychological side effects that often accompany weight loss and reduced appetite