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S, existen formas de estimular la produccin endgena de GLP-1, aunque el efecto es ms moderado que el farmacolgico

The FDA previously approved sermorelin under the brand name Geref for growth hormone deficiency in children before the manufacturer discontinued it for commercial reasons in 2008, not for safety concerns

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However, it is worth considering that routes of administration cannot be easily compared as dose frequency and specific details of the treatment process administration can impact patient preference

In SURMOUNT-1, tirzepatide reached 20.9% mean weight loss at 72 weeks on the highest-dose arm (n=2,539)