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This process requires the involvement of protein disulfide isomerase (PDI), ER redox protein 1 (ERO1), and GRP78 chaperone protein
Reduced glutathione can bind with various exogenous and endogenous toxic substances to generate less toxic compounds
Vitamin E helps to protect enzymes that are dependent on glutathione
J., Majeed, M., & Drummond, P
Polyamines in cancer: integrating organismal metabolism and antitumour immunity
Separately, research has examined DSIPs role in stress axis modulation specifically its effects on corticotropin-releasing hormone (CRH) and ACTH secretion suggesting a potential interface between the sleep regulatory system and the hypothalamic-pituitary-adrenal (HPA) axis
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