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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

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CJC-1295 CJC-1295 is a longer-acting GHRH analog that may be used alongside or instead of Sermorelin in certain treatment protocols

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A manufacturer must have substantiation that the claim is truthful and not misleading and must submit a notification of the claim to the FDA