Recent concerns have arisen as to the potential association between semaglutide and retinopathy progression in diabetics
Here we compare the published data from the STEP-1, SURMOUNT-1, and TRIUMPH-4 trials without marketing spin: -14,9% for semaglutide, -20,9% for the tirzepatide-28,7% for the retatrutideThe retatrutide vs tirzepatide vs semaglutide comparison also incorporates tolerance (dysesthesia 20,9% at the 12 mg dose level of retatrutide), pleiotropic effects 2024-2025 (apnea, heart failure, MASLD), and the updated regulatory status in France 2026
This was a series of prospective observational studies of 3444 weeks duration, performed with the aim of understanding clinical outcomes with oral semaglutide in adults with T2D
doi: 10.1210/endo.142.5.8128 50 BnemannMGerhardsteinBLGaoTHoseyMM
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Most people find that side effects become less intense over time as their bodies get used to the medication