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Retrieved from Blundell, J., Finlayson, G., Axelsen, M., et al
At MPR 0.5, the adjusted HR was quite similar to that in the main analysis (HR 0.87 [0.71-1.06]), but this became lower at MPR 0.75 (HR 0.75 [0.60 0.95]) and lower yet at MPR 0.95 (HR 0.62 [0.46 0.84]) When excluding subjects with follow-up times shorter than 6 months, 25,390 individuals remained, and the unadjusted HR for MOF was found to be 0.86 [0.731.02] for GLP-1 RAs compared to DPP-4is
Research is ongoing and the evidence base continues to develop
Meal Management: Eat smaller, more frequent meals throughout the day instead of large ones
Monitor for any new side effects that emerge at the higher dose
Acrolein can react and form adducts with DNA, lipids and proteins leading to cellular damage in several human tissues
