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Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting gh-releasing hormone analog
Sometimes dramatically better
Historical Background and Scientific Context Scientific interest in synthetic peptides expanded substantially as advances in analytical chemistry and peptide synthesis enabled researchers to investigate increasingly complex molecular communication systems
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The Pharmacology Context CJC-1295 is a modified growth hormone releasing hormone (GHRH) analog
The subcellular localization of the isoenzyme is determined by the presence of organelle-specific targeting peptides and transmembrane domains in the N and C-terminal regions of the protein (Teixeira et al., 2004
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