Class NNMT Inhibitor (Nicotinamide N-methyltransferase) Molecular Weight 193.2 Da (small molecule) Half-life Under investigation Purity 98% (HPLC) Form Powder Storage 20C, dry, protected from moisture Reconstitution DMSO or sterile water (partial solubility) Mechanism of action 5-Amino-1-methylquinolinium (5-Amino-1MQ) is a competitive inhibitor of NNMT an enzyme overexpressed in adipose tissue in obesity that converts nicotinamide to 1-methylnicotinamide while consuming SAM (S-adenosyl methionine)
And protein kinase A phosphorylates hormone-sensitive lipase, the enzyme that physically breaks triglycerides apart into free fatty acids and glycerol
The process typically begins within hours of administration and can remain active for 12-24 hours based on the sustained activation of lipolytic enzymes and metabolic pathways
The good news is, early studies and clinical experience suggest it can be a safe and effective tool when used correctly and under professional guidance
It exists as a dietary supplement ingredient with promising preclinical research but without the level of human evidence required for drug status
By blocking NNMT, 5-Amino-1MQ helps conserve nicotinamide, allowing for increased NAD+ synthesis