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doi: 10.3389/fimmu.2026.1755316 Received 27 November 2025 Revised 11 July 2026 Accepted 22 July 2026 Published 03 August 2026 Volume 17 - 2026 Edited by Manuel Muro, Virgen de la Arrixaca University Hospital, Spain Reviewed by Paola Pontrelli, University of Bari Aldo Moro, Italy Benjamin Spector, University of Wisconsin-Madison, United States Updates Copyright 2026 Zhang, Zheng, Zheng, He, Chen, Luo, Wang and Cai

Daily totals: 1,600 calories, 145g protein (36%), 155g carbs (39%), 44g fat (25%) This plan gives more flexibility

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Any observed associations are more likely related to secondary factors such as hydration status or pre-existing patient risk factors

In both studies, participants randomly received either 10 or 15 milligrams of Zepbound or placebo once weekly for 52 weeks

While GLP-1 receptor agonists like semaglutide and tirzepatide produce significant weight loss, their effect on cellulite appearance remains unpredictable