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Science , 2022, 375: 12541261 Ruiz LM, Libedinsky A, Elorza AA

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The mechanism of GLP-1-induced nausea involves central GLP-1R activation in the brainstem, specifically in the area postrema, which is the chemoreceptor trigger zone for vomiting

GLP-1RAs were documented to normalise insulin resistance and modulate dopaminergic signalling reducing anhedonia and influencing food cue reactivity

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