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It is also involved in numerous biochemical reactions such as protein and DNA synthesis and enzymatic activation, affecting virtually every system in the body, particularly the gastrointestinal, respiratory, nervous and immune systems

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42 In terms of time series, intracellular zinc serves as a second messenger, and its concentration transients are divided into two main types: early (fast) zinc signaling (EZS) and late zinc signaling (LZS) 43 (Fig

Metformin is believed to cause substantial changes in the composition and operation of the intestinal microbiome, as stated by several studies (Forslund et al., 2015

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Second, freeze-concentration effects increase local peptide concentration in the remaining liquid fraction, promoting aggregation