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In a rat model of cerebral ischemia-induced neurological impairment, the co-administration of tissue plasminogen activator (tPA) with nanoliposomal Fasudil-Lip showed better neuroprotection, and prolonged therapeutic time window (TTW) and improved drug targeting (Fukuta et al., 2017)
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Furthermore, expression of SLC7A11, a GSTO1 and C1-27 target gene, was increased in C1-27 -treated tumours indicating target engagement (Fig
The same multi-dose vial benefits apply in these specialized settings
Skin experiences the highest load of oxidative stress when compared to all other organs in the body
nevertheless, as these confounding factors underlie all groups, it is unlikely that these factors affect the conclusion
