Insufficient dosing is perhaps the most common issue
For Ozempic and Mounjaro prescribed for type 2 diabetes, Anthem usually requires a recent A1C result of 7.0% or higher and documentation that the patient is on or has tried metformin (unless contraindicated)
For practical purposes, calculate how long a vial will last based on your dosing protocol and reconstitute accordingly
This dual action appears to amplify appetite suppression and metabolic regulation beyond what GLP-1 activation alone produces, which is why clinical trials consistently show greater average weight loss with tirzepatide
In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]
Reference: Wharton S, et al