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Polyphenol-Rich Foods Polyphenols such as EGCG (green tea), quercetin (onions, apples), and anthocyanins (berries) stimulate GLP-1 secretion and improve insulin sensitivity (Domnguez vila et al., 2017).* Polyphenols also modulate gut microbiota composition, favoring SCFA-producing strains.* 3

To groups of five anaesthetized rats, peptides (exenatide or semaglutide) in sterile Dulbeccos phosphate buffer saline (DPBS) (Biowest, L0615) were administered by intravenous injection via the tail vein

6 Assessment of MK-801 as a half-life extender of gut peptide hormones

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The researchers commented that the peptide suppressed caspase-dependent apoptosis that increases during aging of cell cultures. By potentially restraining Caspase-3 activity, Epithalon might support cellular longevity and decrease apoptosis, enhancing its regenerative capabilities

Inflammatory Signaling and Cytoprotective Pathways Research literature also explores how these peptides influence cellular stress responses and inflammatory signaling