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The HPA activation is present but typically less pronounced in head-to-head studies

Our data indicate an increased risk of vomiting and nausea side effects associated with the Gln allele in tirzepatide-treated patients, which may result from a diminished ability of the GIP component of the drug to buffer the nausea-inducing effects of the GLP1 component

A new clinical trial also showed GLP-1 therapies raise visceral fat metabolic activity, linking this energy-burn effect to greater weight loss

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This strong warmth can be very intense, making these areas feel much hotter than usual, which is hard to ignore