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These events occurred mainly during the early phase of treatment when the dose was being titrated up

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The starting dose is typically 0.25 mg per week, gradually increasing over several months to a maintenance dose of 1 mg or 2 mg per week depending on how your body responds

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This may have introduced prescription bias, particularly given the relatively balanced group sizes

patients should speak to their GP or visit the NIHR Be Part of Research portal for information on eligible trials