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doi: 10.1056/NEJMoa1607141 12 HernandezAFGreenJBJanmohamedSD'AgostinoRBSrGrangerCBJonesNPet al

Vitamin B6 contributes to the reduction of tiredness and fatigue

It reduces appetite, slows digestion, and supports more effective insulin use

TREM2 agonists, such as AL002, promote microglial transformation toward the anti-inflammatory M2 phenotype, thereby reducing the release of pro-inflammatory M1 cytokines (e.g., TNF-, IL-1) and indirectly mitigating inflammation-driven ferroptotic cascades

Melasma can return if triggers such as sun exposure or hormones persist