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This is a potentially dangerous condition called hypoglycemia unawareness
Treatment with GLP-1RAs can provide supraphysiologic and sustained stimulation of the GLP-1 receptor
This is relevant for the short-acting GLP-1 agonists, whereas tachyphylaxis rapidly develops for the long-acting agonists [8]
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Since GLP-1 agonists are effective in reducing appetite and promoting weight loss, they have become an increasingly common prescription for individuals who meet certain weight or health criteria, even if they do not have diabetes
It has a neuroendocrine pathway independent of the GLP-1 receptors, working by stimulating melanocortin-4 receptors (MC4R) to reduce hunger and increase basal metabolic rate
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