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Psychiatry 31 , 231236 (2018)

The efficacy of molecularly targeted therapeutics may be highly selective in cancer patients

Essien, MD, MPH, assistant professor of medicine at the University of Pittsburgh School of Medicine and core investigator in the Center for Health Equity and Research Promotion at the VA Pittsburgh Healthcare System, and colleagues wrote that as novel, effective and often costly drugs are approved for use and incorporated into clinical practice guidelines, a disturbing pattern of care is evident: Uptake and diffusion of recommended, evidence-based therapies increase over time, whereas individuals from underrepresented racial and ethnic groups receive these medications less often

The role of the mitochondria in ferroptosis, as understood today, is a metabolic one

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Since our results showed that SUN induced no effect on MCD mRNA expression and protein level, therefore increased carboxylation of acetyl-CoA by ACC2 but not degradation of malonyl-CoA by MCD is the only explanation for the observed increase in malonyl-CoA production in cardiac tissues