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In one study, repeated topical 5% DHA application in hairless dogs led to irritant contact dermatitis, with histopathological findings of epidermal thickening, degeneration, and inflammatory changes, while vehicle-only controls showed no such effects, indicating DHA as the causative agent
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Animals were assigned to study groups based on their starting body weights to ensure equal unbiased distribution at the cage level
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News Peg Novo Nordisk ended a separate trial of the drug looking at kidney disease last year far earlier than originally expected on account of the positive results
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