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Taken together, our results indicate that GIPR in the AP underlie the weight loss effects of GIPR agonism, whereas GIPR in the hypothalamus underlie the additional weight loss effects of adding GIPR antagonism to GLP-1R or amylin receptor agonism

Friedmann, T

Ultimately, the decision to choose between tirzepatide and retatrutide should be guided by personal health profiles, weight loss objectives, and tolerance for side effects

Those who were then randomly assigned to keep taking the drug for 48 more weeks lost another 16 pounds, while those who were switched to a placebo for those 48 weeks gained 13 pounds

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