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In respect to their cardiovascular effects among patients with T2DM, both GLP-1RAs and SGLT2is have been shown to reduce the risk of MACE (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke), with GLP-1RAs reducing the risk of non-fatal stroke to a greater extent [3, 6]
Published studies in animal models have reported effects on fibroblast activity the cells responsible for producing collagen and structural proteins as well as collagen organization and tissue remodeling signals
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
demonstrates that GHK-Cu promotes ECM component synthesis while simultaneously modulating matrix metalloproteinase (MMP) activity (Pickart & Margolina, Biomedicines, 2018)
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