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Most side effects are mild, including nausea, bloating, or constipation during the first few weeks
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Both metformin and long-term use of proton pump inhibitors have been linked to reduced B12, and the same goes for many people past 50
While extensive trials in human subjects are lacking, studies to date in both animal and human models are highly favorable
Some people switch because weight loss slowed down, while others switch because they want improved appetite control or better tolerance
however, accumulation with chronic injectable use has not been characterized in long-term published studies
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