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In functional medicine and longevity-focused care, we use it strategically in patients with: High visceral fat on imaging or InBody Central adiposity resistant to diet and exercise Low IGF-1 with metabolic dysfunction Early fatty liver patterns Why Its Different from GLP-1s GLP-1 medications reduce appetite and slow gastric emptying

Human pharmacokinetics, doseresponse, and mechanism validation remain limited

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For example, Ozempic is covered only to treat diabetes, and Wegovy is covered for the indication of Major Adverse Cardiovascular Events (MACE) reduction in overweight/obese adults, but neither are currently covered for obesity as a standalone condition

Berberine and Its Role in Chronic Disease