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Some even lost up to 24% of their body weight

Therefore, the relationship between the rate of weight loss and the rate of weight regain remains inconclusive and a more comprehensive systematic analysis is still needed

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they answer different research questions, and the choice is a design decision rather than a dosing one

Cross-Trial Context# Retatrutide's 24.2% weight loss at 48 weeks appears numerically superior to semaglutide's 14.9% at 68 weeks, but several factors complicate direct comparison: Trial phase : Phase 2 trials often yield more favorable results than Phase 3 (smaller, more controlled populations) Treatment duration : Semaglutide data are at 68-104 weeks

Pellagra and Its Prevention and Control in Major Emergencies