NMDA receptors are associated with glutamate, an essential excitatory neurotransmitter in the brain, while GABA receptors are linked to inhibitory neurotransmission, which is considered crucial for reducing neural activity and inducing a relaxed state
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doi:10.1053/meta.2000.6250
This loss of equilibrium in drug abusers may increase risk of metabolic dysfunctions which may result in worsening addiction and possible disease states such as those manifested as the metabolic syndrome
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