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In line with this notion, pharmacologic or genetic suppression of GLP-1R in the lateral septum attenuates the ability of cocaine to activate the mesolimbic dopamine system, as assessed by hyperactivity, reward in the CPP test, and dopamine enhancement in the NAc ( via arachidonic acid and the increased expression of the dopamine transporter within the lateral septum ( Although the vast majority of studies have revealed interactions between cocaine responses and GLP-1R, some studies have reported correlations between the responses to cocaine and the plasma levels of GLP-1

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Ben-Shlomo et al

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