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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases

SM: Data curation, Investigation, Writing review & editing

Lipids 170 SmithR

That is why GLP-1 drugs for heart protection in autoimmune disease now attract attention

Ruben Morones-Ramirez, Ph.D., a former postdoctoral fellow on Collins team who is now a professor at Universidad Autnoma de Nuevo Leon in Mexico

Research has consistently found that healthy long-term weight management is strongly associated with diets that emphasise a diversity of whole foods across all major food groups.