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10.1016/S0300-483X(03)00290-7 Toxicology 50 FromerM.PanosR.SiebertsS

This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors

These results suggest that leptin deficiency is responsible for the downregulation of exons IV and VI expression, but not exons II and III