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Shanzhiside methyl ester (SM), the major iridoid glycoside of Lamiophlomis rotata , demonstrated dose-dependent and long-lasting anti-allodynic effects in neuropathic rats without inducing tolerance [42]

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This treatment demonstrates significant reductions in HbA1c levels while effectively managing key CV risk factors such as weight, blood pressure, and lipid profiles, potentially lowering the risk of future CV events [Table 1]

GLP-1 receptors are present not only in the pancreas but also extensively throughout the gastrointestinal system