The MCO occurs in vitro by Fenton reaction whereby ascorbic acid and iron-chloride generate highly reactive oxygen species (ROS such as hydroxyls) that react with proteins and generate carbonyl groups on susceptible amino acids 5
Le Trong I, Stenkamp RE, Ibarra C, Atkins WM, Adman ET
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Mitochondrial inhibitor rotenone triggers and enhances neuronal ferroptosis following intracerebral hemorrhage
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