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Observational studies of people with diabetes [47, 48] that addressed immortal time bias [34] found no association between dementia risk and initiation of metformin, a first-line therapy for type 2 diabetes

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The incidence of adverse events underscores the importance of careful dose management and patient monitoring during treatment

LH injections of GLP-1/estrogen reduced food intake more than GLP-1 or estrogen-only, which showed that this effect might be sex-biased (Vogel et al., 2016)