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In adults, chronic pain, gastrointestinal and genitourinary problems, fatigue, restricted mobility, and frequent injuries were most often associated with the functional outcomes of decreased perceived quality of life and decreased participation in activities of daily living

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doi: 10.1111/dom.14255 29 QuastDRNauckMASchenkerNMengeBAKapitzaCMeierJJ

The area postrema (AP) in the brainstem is characterized by an open blood-brain barrier and has a high density of amylin receptors