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reported that semaglutide accessed the brainstem, hypothalamus, and the dorsal half of the septal area, largely via small circumventricular organs, but it was not shown to cross the BBB [27]

In preclinical models, these approaches have been associated with ECM loosening, increased penetration distance from vessels, enhanced immune cell infiltration and delayed tumor growth [70, 96, 97]

Additionally, the use of tripeptides derived from animal sources, such as bovine and porcine, may raise social, religious, and cultural concerns

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Toft-Nielsen, M