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In our bulk RNAseq data, we noted that pathways such as oxidative phosphorylation and electron transport chain were significantly downregulated ( Supplementary Figures 5B, C )

Mol Pharmacol 1996

Contrave is an oral extended-release medication that contains two active ingredients: bupropion (an antidepressant, also found in the medicine Wellbutrin) and naltrexone (an opioid antagonist)

Over the past two decades, it has consistently demonstrated multimodal geroprotective effects across cellular, animal, and early human studies

The membrane was saturated in Tris-buffered saline supplemented with 1% Tween 20 (TBS-T) and 5% skimmed milk, at room temperature (RT) for 1 h

Importantly, Mounjaro delays gastric emptying, which may affect the absorption of oral medicines, including oral contraceptives