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In this study we used model compounds as well as alkaline phosphatase to test this idea

Acta 1848, 561567

GLP-1 receptors are expressed in pancreatic islet -cells, pulmonary epithelial cells, atrial cardiac myocytes, vagal afferent neurons, neurons in a number of brain regions, as well as cells lining gastric pits and small intestinal mucosa

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For many individuals, these effects attenuate over time as physiological adaptation occurs, though some patients continue to experience persistent symptoms throughout treatment

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