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Most patients notice initial darkening within 3-5 days of starting the loading phase, with progressive tan development over 1-2 weeks

Metabolic adaptation, the body resetting its energy balance to a lower expenditure level during weight loss, means that the post-treatment metabolic rate is lower than before treatment began

Yuan J, Wang M, Pan Y, et al

1.2 Commercial Evolution of GLP-1 Therapies 1.2.1 Novo Nordisks Early Lead Novo Nordisk dominated early

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