Presently, there is a scarcity of research on the effect of GLP-1RAs in autoimmune diseases such as ankylosing spondylitis (AS) and uveitis
GLP-1 medications, including the oral semaglutide pill, are generally well-tolerated by many patients
The pill works through SNAC technology, a specialized absorption enhancer that temporarily raises the pH of the stomach lining and facilitates semaglutide absorption through the gastric wall
But these properties are not sufficient reason to prescribe tirzepatide to someone who would not otherwise be a candidate
This is a new, practical safety concern that surgical societies are rushing to address
2013;110(22):9066-9071 doi:10.1073/pnas.1219451110 (Animal) Depommier C, Everard A, Druart C, et al