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These molecular changes alter the medication's pharmacokinetic and pharmacodynamic properties, potentially leading to reduced therapeutic efficacy or unpredictable effects
GLP-1/Glucagon Receptor Co-Agonism for Treatment of Obesity
( h-i ) KG abundance in cells treated with the IDH1 inhibitor ( h ) or cultured under glutamine starvation (GS) ( i ) (n = 8 technical replicates representative from 2 independent experiments)
doi:10.1097/01.prs.0000034327.02735.4e Souza FM, Collett-Solberg PF
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For patients with type 2 diabetes, the American Diabetes Association (ADA) Standards of Care emphasize individualized glycemic targets and treatment selection based on patient-specific factors including baseline hemoglobin A1c (HbA1c), presence of atherosclerotic cardiovascular disease (ASCVD), heart failure, or chronic kidney disease, hypoglycemia risk, weight considerations, and patient preferences
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