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Given that their high toxicity may provoke serious side effects, researchers are proposing different ways to reduce their toxicity without decreasing their efficacy

B-100 complex can interfere with other medicines including but not limited to: levodopa, medicines containing oestrogen, hydrazine, certain anti epileptic drugs, phenobaritone, phenytoin, immunosuppressants and some drugs used to treat infections such as isoniazid, pyrazinamide, cycloserne and penicillamine

MTX reduced the intensity of E2FB expression and restricted it to the cells of the root cap

these processes lead to partial functional recovery [59] or the formation of the neural fiber connection between the central pattern generator (CPG) and interneurons in the spinal cord, which can enable rhythmic movement [60,61,62]

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